Is there a gap between how you'd like things to be and how they are?
It may be a small gap or a freaking enormous ravine, but that gap is, in fact, probably the primary cause of pain and unhappiness for most people. What if you said 'F**k It' to the idea of how your life should be and found peace with your life just as it is? That's going to shake things up and take the edge of your pain and discomfort way more than any pill could.
John C. Parkin, the maestro of saying 'F**k It', realized as he worked with people on his retreats that we can close that gap not by striving to be different, changing the world or even learning how to peaceful - but by saying 'F**k It' and making our peace with life, just as it is. Being at peace with life doesn't necessarily mean being peaceful, and it certainly isn't being passive; it means embracing life in all its colours.
This is a radical message that can create radical shifts in your perception of life, just as it is.