Pulmonary and critical care specialist Dr. Phineas Mann is fighting a losing battle with a severe, progressive form of Parkinson's disease. He is accepted into a novel trial to insert programmed stem cells into his brain. This experimental treatment is his last desperate hope to reverse his debilitating Parkinson's symptoms.

While grappling with his own declining health, Phineas is asked to consult on a difficult case. The patient is conservative congressman Quentin Tate, whose misdiagnosed lung condition has rapidly worsened. Phineas draws on his decades of experience in a quest to identify the cause of Tate's rare and life-threatening disease.

Then his wife, Iris, develops an obscure blood disorder. When her medical specialist orders a surprising and risky treatment, Phineas is compelled to bring his keen eye and medical knowledge into her struggle. Time is his enemy as he, with his loyal service dog Ernest at his side, fights to save his beloved Iris, then himself.